The protective effect of niacinamide on ischemia-reperfusion-induced liver injury.

@article{Chen2001ThePE,
  title={The protective effect of niacinamide on ischemia-reperfusion-induced liver injury.},
  author={C F Chen and David Daoyi Wang and Carl Philip Hwang and Hui Liu and Jian-an Wei and Ru Ping Lee and Hsing I. Chen},
  journal={Journal of biomedical science},
  year={2001},
  volume={8 6},
  pages={446-52}
}
Reperfusion of ischemic liver results in the generation of oxygen radicals, nitric oxide (NO) and their reaction product peroxynitrite, all of which may cause strand breaks in DNA, which activate the nuclear enzyme poly(ADP ribose)synthase (PARS). This results in rapid depletion of intracellular nicotinamide adenine dinucleotide and adenosine 5… CONTINUE READING