The protective effect of losartan in the nephropathy of the diabetic rat includes the control of monoamine oxidase type A activity.

Abstract

Monoamine oxidase activity (MAO-A and B) levels, as intracellular source of reactive oxygen species, might increase in diabetic nephropathy (DN) contributing to reduce dopamine levels and to unbalance kidney redox state. We explored the hypothesis that beneficial effects of losartan, an angiotensin-II type 1 receptor (AT1) blocker, in DN included the… (More)
DOI: 10.1016/j.phrs.2011.11.010

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