The protective effect of erdosteine against ototoxicity induced by cisplatin in rats

@article{Kalcioglu2004ThePE,
  title={The protective effect of erdosteine against ototoxicity induced by cisplatin in rats},
  author={Mahmut Tayyar Kalcioglu and Ahmet Kizilay and Mukaddes Gulec and Erkan Karataş and Mustafa Iraz and Omer Akyol and Mucahit Egri and Orhan Ozturan},
  journal={European Archives of Oto-Rhino-Laryngology and Head & Neck},
  year={2004},
  volume={262},
  pages={856-863}
}
The elimination of cisplatin ototoxicity is an ongoing concern. This experimental study was undertaken to investigate the effect of oral erdosteine in ameliorating cisplatin-induced ototoxicity. Twenty-eight adult female Wistar albino rats were randomly divided into four equal groups. Group A received an oral carrier vehicle of the drug erdosteine with 0.2 ml of 0.9% saline. Group B was administered only erdosteine (per oral 10 mg/kg twice a day) for 6 days. Group C was injected with cisplatin… CONTINUE READING