The protective effect of caffeic acid phenethyl ester against cyclosporine A-induced cardiotoxicity in rats.

@article{Rezzani2005ThePE,
  title={The protective effect of caffeic acid phenethyl ester against cyclosporine A-induced cardiotoxicity in rats.},
  author={Rita Rezzani and Lorena Giugno and Barbara Buffoli and Francesca Bonomini and Roberto Bianchi},
  journal={Toxicology},
  year={2005},
  volume={212 2-3},
  pages={155-64}
}
Cyclosporine A (CsA) is the immunosuppressor, which is most frequently used in transplant surgery and in the treatment of autoimmune diseases. Oxidative stress has been considered as one of the possible mechanisms of CsA-induced cardiotoxicity. The present investigation examines the ability of caffeic acid phenethyl ester (CAPE), which is an active component of propolis extracts, as a natural antioxidant to protect against CsA-induced oxidative stress and cardiotoxicity. CsA cardiotoxicity was… CONTINUE READING