The protective effect of alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose.

@article{Sun2012ThePE,
  title={The protective effect of alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose.},
  author={Lian-Qing Sun and Ying-ying Chen and Xuan Wang and Xiao-jin Li and Bing Xue and Ling Qu and Ting-ting Zhang and Yi-ming Mu and Ju-ming Lu},
  journal={Biochemical pharmacology},
  year={2012},
  volume={84 7},
  pages={961-73}
}
Diabetic peripheral neuropathy (DPN) is one of the most common and costly microvascular complications of diabetes, and no effective therapy exists. Previous studies have demonstrated that oxidative stress may be the unifying factor for the damaging effect of hyperglycemia. The aim of this study was to examine the impact of treatment with Alpha lipoic acid (ALA) on the intermittent high glucose (IHG) or high glucose (HG)-induced oxidative stress-induced mitochondrial pathway activation and… CONTINUE READING

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