The protective effect of adenosine A2A receptor antagonism in cerebral ischemia.

@article{Pedata2005ThePE,
  title={The protective effect of adenosine A2A receptor antagonism in cerebral ischemia.},
  author={Felicita Pedata and Marco Gianfriddo and Daria Turchi and Alessia Melani},
  journal={Neurological research},
  year={2005},
  volume={27 2},
  pages={169-74}
}
OBJECTIVES We reviewed our most recent work on the protective effect of adenosine A(2A)antagonism in cerebral ischemia. METHODS Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin. RESULTS A(2A) antagonism was found protective in the model of permanent focal ischemia induced by the monofilament technique. This methodology provides the possibility of evaluating the… CONTINUE READING