The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum.

@article{Fricke2007ThePM,
  title={The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum.},
  author={Benjamin Fricke and Sylvia Heink and Janos Steffen and Peter M Kloetzel and Elke Kr{\"u}ger},
  journal={EMBO reports},
  year={2007},
  volume={8 12},
  pages={1170-5}
}
The quality control of proteins mediated by the plasticity of the proteasome system is regulated by the timely and flexible formation of this multisubunit proteolytic enzyme complex. Adaptable biogenesis of the 20S proteasome core complex is therefore of vital importance for adjusting to changing proteolytic requirements. However, the molecular mechanism and the cellular sites of mammalian proteasome formation are still unresolved. By using precursor complex-specific antibodies, we now show… CONTINUE READING

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