The proteasome is required for rapid initiation of death receptor-induced apoptosis.

@article{Sohn2006ThePI,
  title={The proteasome is required for rapid initiation of death receptor-induced apoptosis.},
  author={Dennis Sohn and Gudrun Totzke and Frank Essmann and Klaus Schulze-Osthoff and Bodo Levkau and Reiner U. J{\"a}nicke},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 5},
  pages={1967-78}
}
Due to their tremendous apoptosis-inducing potential, proteasomal inhibitors (PIs) have recently entered clinical trials. Here we show, however, that various PIs rescued proliferating tumor cells from death receptor-induced apoptosis. This protection correlated with the stabilization of X-linked IAP (XIAP) and c-FLIP and the inhibition of caspase activation. Together with the observation that PIs could not protect cells expressing XIAP or c-FLIP short interfering RNAs (siRNAs) from death… CONTINUE READING