The proteasome is a major autoantigen in multiple sclerosis.

  title={The proteasome is a major autoantigen in multiple sclerosis.},
  author={Isabel Mayo and Joaqu{\'i}n Arribas and Pablo Villoslada and Rita {\'A}lvarez Doforno and Susana Rodr{\'i}guez-Vilari{\~n}o and Xavier Montalban and Mar{\'i}a Rosa de Sagarra and Jos{\'e} G Casta{\~n}o},
  journal={Brain : a journal of neurology},
  volume={125 Pt 12},
Multiple sclerosis seems to be an autoimmune disease of unknown aetiology affecting the white matter of the CNS. It is generally accepted that the autoimmune response is directed against specific components of myelin. We show here that proteasome, a ubiquitous protease complex composed of 14 different subunits, is a target for autoantibodies (IgG and IgM classes) present in the serum (66%, 73 out of 110) and in the CSF (61%, 16 out of 26) of patients with multiple sclerosis. Using recombinant… CONTINUE READING