The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture.

Abstract

BACKGROUND/AIMS Crucial steps in the initiation of lupus nephritis are the deposition of (auto-)antibodies and consequent complement activation. In spite of aggressive treatment patients may develop terminal renal failure. Therefore, new treatment strategies are needed. In extension to our previously published data we here analyzed the potential… (More)
DOI: 10.1159/000334955

Topics

10 Figures and Tables

Cite this paper

@article{Hainz2012ThePI, title={The proteasome inhibitor bortezomib prevents lupus nephritis in the NZB/W F1 mouse model by preservation of glomerular and tubulointerstitial architecture.}, author={Nadine Hainz and Susanne B. Thomas and Kirsten Neubert and Silke Meister and Kerstin Benz and Manfred Rauh and Christoph Daniel and Michael Sean Wiesener and Reinhard Edmund Voll and Kerstin Amann}, journal={Nephron. Experimental nephrology}, year={2012}, volume={120 2}, pages={e47-58} }