The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

@article{Hideshima2001ThePI,
  title={The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.},
  author={Teru Hideshima and Paul Richardson and Dharminder Chauhan and Vito J. Palombella and Peter J. Elliott and Julian Adams and Kenneth C. Anderson},
  journal={Cancer research},
  year={2001},
  volume={61 7},
  pages={3071-6}
}
Human multiple myeloma (MM) is a presently incurable hematological malignancy, and novel biologically based therapies are urgently needed. Proteasome inhibitors represent a novel potential anticancer therapy. In this study, we demonstrate that the proteasome inhibitor PS-341 directly inhibits proliferation and induces apoptosis of human MM cell lines and freshly isolated patient MM cells; inhibits mitogen-activated protein kinase growth signaling in MM cells; induces apoptosis despite induction… CONTINUE READING
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