The proteasome inhibitor MLN-273 blocks exoerythrocytic and erythrocytic development of Plasmodium parasites.

@article{Lindenthal2005ThePI,
  title={The proteasome inhibitor MLN-273 blocks exoerythrocytic and erythrocytic development of Plasmodium parasites.},
  author={C Lindenthal and Nadine Weich and Yi Shi Michelle Chia and Volker T Heussler and Mo Quen Klinkert},
  journal={Parasitology},
  year={2005},
  volume={131 Pt 1},
  pages={37-44}
}
Protein degradation is regulated during the cell cycle of all eukaryotic cells and is mediated by the ubiquitin-proteasome pathway. Potent and specific peptide-derived inhibitors of the 20S proteasome have been developed recently as anti-cancer agents, based on their ability to induce apoptosis in rapidly dividing cells. Here, we tested a novel small molecule dipeptidyl boronic acid proteasome inhibitor, named MLN-273 on blood and liver stages of Plasmodium species, both of which undergo active… CONTINUE READING
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