The proteasome function is required for Mycobacterium leprae-induced apoptosis and cytokine secretion.

@article{Fulco2007ThePF,
  title={The proteasome function is required for Mycobacterium leprae-induced apoptosis and cytokine secretion.},
  author={Tatiana de Oliveira Fulco and Ulisses Gazos Lopes and Euzenir Nunes Sarno and Elizabeth Pereira Sampaio and Alessandra Mattos Saliba},
  journal={Immunology letters},
  year={2007},
  volume={110 1},
  pages={82-5}
}
Previous studies have demonstrated the importance of the ubiquitin-proteasome pathway in the immune response to bacterial pathogens. To investigate the role of this system in the context of leprosy, Mycobacterium leprae-stimulated peripheral blood mononuclear cells (PBMC) were treated with the proteasome inhibitor MG132 to assess the levels of apoptosis and cytokine secretion. The results showed that the inhibition of proteasome activity significantly reduced M. leprae-mediated cell death. In… CONTINUE READING