The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination

Abstract

Although RAD52 plays a critical role in the initiation of homologous recombination (HR) by facilitating the replacement of RPA with RAD51, the mechanism controlling RAD52 remains elusive. Here, we show that Bag101, a factor implicated in proteasome functioning, regulates RAD52 protein levels and subsequent HR. LC-MS/MS analysis identified Bag101 which binds… (More)
DOI: 10.1038/srep02022

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