The proteasome can cleave a caspase-3 substrate


Using ion chromatography and gel filtration we showed that at acidic pH values a caspase-3 substrate may be cleaved by different proteases of the brain. Previously, we showed that one of these enzymes is cathepsin B. Here, we used substrate analysis and Western blotting and found that the proteasome has the capacity to cleave a caspase-3 substrate at acidic… (More)
DOI: 10.1134/S1819712412030154


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