The proteasome activity reporter GFP-Cl1 is degraded by autophagy in the aging model Podospora anserina

@inproceedings{Wiemer2014ThePA,
  title={The proteasome activity reporter GFP-Cl1 is degraded by autophagy in the aging model
Podospora anserina
},
  author={Matthias Wiemer and Heinz D. Osiewacz and Thorsten Hoppe and Martina P Liebl and Suresh I S Rattan and Nektarios Tavernarakis},
  booktitle={F1000Research},
  year={2014}
}
The degradation of damaged proteins is an important vital function especially during aging and stress. The ubiquitin proteasome system is one of the major cellular machineries for protein degradation. Health and longevity are associated with high proteasome activity. To demonstrate such a role in aging of Podospora anserina, we first analyzed the transcript… CONTINUE READING