The protease inhibitor cystatin C down‐regulates the release of IL‐β and TNF‐α in lipopolysaccharide activated monocytes

@article{Gren2016ThePI,
  title={The protease inhibitor cystatin C down‐regulates the release of IL‐$\beta$ and TNF‐$\alpha$ in lipopolysaccharide activated monocytes},
  author={Susanne Thiesen Gren and Sabina Janciauskiene and Salipalli Sandeep and Danny D. Jonigk and Peter Helding Kvist and Jens Gammeltoft Gerwien and Katarina H{\aa}kansson and Olof Grip},
  journal={Journal of Leukocyte Biology},
  year={2016},
  volume={100}
}
Human cystatin C, a member of the cysteine proteinase‐inhibitory family, is produced by all nucleated cells and has important roles in regulating natural immunity. Nematode homologs to human cystatin C have been shown to have anti‐inflammatory effects on monocytes and to reduce colitis in mice. In Crohn's disease, pathogenic activated monocytes help drive inflammatory processes via the release of proinflammatory cytokines and chemokines. In particular, tumor necrosis factor‐α–producing… 

Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice

It is demonstrated that the excessive inflammatory response to the LPS-induced sepsis in CstC KO mice is dependent on increased caspase-11 expression and impaired autophagy, but is not associated with increased cysteine cathepsin activity.

Inhibition of lipopolysaccharide‐induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors

It is concluded that cysteine proteinase inhibitors effectively inhibit LPS‐induced osteoclast formation in vivo and in vitro by inhibition of TNF‐α expression.

Secreted cystatins decrease proliferation and enhance apoptosis of human leukemic cells

External addition of cystatins C and D to HL‐60 and Jurkat cells demonstrated similar degrees of cystatin D uptake and decreased viability as for U937 cells, indicating that these effects are general for leukemic cells.

The Role of Cysteine Peptidases in Hematopoietic Stem Cell Differentiation and Modulation of Immune System Function

The aim of the present article is to review the mechanisms of dysregulation of cysteine cathepsins and their inhibitors in relation to immune dysfunction to address new possibilities for regulation of their function.

Antimicrobial and anti-inflammatory activity of Cystatin C on human gingival fibroblast incubated with Porphyromonas gingivalis

Information on the antimicrobial and immunomodulatory properties of cystatin C could aid in the design of new therapeutic approaches to facilitate the elimination of this bacterium to improve the treatment of periodontal disease.

Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation

CysC is upregulated under obesity conditions and thereby counteracts inflammation of peripheral insulin-sensitive tissues and, thus, obesity-associated deterioration of glucose metabolism.

Correlation between intestinal flora and serum inflammatory factors in patients with Crohn's disease.

It is concluded that monitoring the changes in distribution and composition of intestinal flora as well as the levels of blood inflammatory factors could play a significant role in the treatment process of Crohn's disease.

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