The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation

@article{Futai1999ThePA,
  title={The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation},
  author={Eugene Futai and Takashi Maeda and Hiroyuki Sorimachi and Katsuhiko Kitamoto and Sho-ichi Ishiura and Ken-Ichi T Suzuki},
  journal={Molecular and General Genetics MGG},
  year={1999},
  volume={260},
  pages={559-568}
}
Saccharomyces cerevisiae has only one putative gene (designated CPL1) for a cysteine protease with a protease domain similar to that of calpain. This gene product shows significant sequence similarity to PalBp, a fungal (Emericella nidulans) calpain-like protease that is responsible for adaptation under alkaline conditions, both in the protease domain and the domain following the protease domain. CPL1 disruptant strains show impaired growth at alkaline pH, but no obvious growth defects under… CONTINUE READING

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