The prostate cancer-associated human retrovirus XMRV lacks direct transforming activity but can induce low rates of transformation in cultured cells.

@article{Metzger2010ThePC,
  title={The prostate cancer-associated human retrovirus XMRV lacks direct transforming activity but can induce low rates of transformation in cultured cells.},
  author={Michael J Metzger and Christiana Holguin and Ramon Mendoza and A Dusty Miller},
  journal={Journal of virology},
  year={2010},
  volume={84 4},
  pages={
          1874-80
        }
}
The human retrovirus XMRV (xenotropic murine leukemia virus-related virus) is associated with prostate cancer, but a causal relationship has not been established. Here, we have used cultured fibroblast and epithelial cell lines to test the hypothesis that XMRV might have direct transforming activity but found only rare transformation events, suggestive of indirect transformation, even when the target cells expressed the human Xpr1 cell entry receptor for XMRV. Characterization of cells from… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.

  • The Journal of clinical investigation
  • 2016
VIEW 2 EXCERPTS
CITES BACKGROUND

The tale of xenotropic murine leukemia virus-related virus.

  • The Journal of general virology
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL