The prostanoid EP2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey.

@article{Nilsson2006ThePE,
  title={The prostanoid EP2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey.},
  author={Siv F. E. Nilsson and Enken Drecoll and Elke L{\"u}tjen-Drecoll and Carol B. Toris and Achim H-P Krauss and Alexander B Kharlamb and Amelia L Nieves and Teresa Guerra and David F. Woodward},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 9},
  pages={4042-9}
}
PURPOSE To investigate the ocular hypotensive effect of the prostanoid EP2 receptor agonist butaprost and to establish its mechanism of action. METHODS All experiments were performed in cynomolgus monkeys after topical application of butaprost (0.1%). The effects of butaprost on aqueous humor flow were determined by fluorophotometry. Total outflow facility was measured by the two-level, constant-pressure perfusion method, and uveoscleral outflow was determined by perfusion of FITC-labeled… CONTINUE READING
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