The prostaglandin transporter regulates adipogenesis and aromatase transcription.

@article{Subbaramaiah2011ThePT,
  title={The prostaglandin transporter regulates adipogenesis and aromatase transcription.},
  author={Kotha Subbaramaiah and Clifford A. Hudis and Andrew J. Dannenberg},
  journal={Cancer prevention research},
  year={2011},
  volume={4 2},
  pages={194-206}
}
Cytochrome P450 aromatase, encoded by the CYP19 gene, catalyzes estrogen synthesis. In obese postmenopausal women, increased estrogen synthesis in adipose tissue has been linked to hormone-dependent breast carcinogenesis. Hence, it is important to elucidate the mechanisms that regulate CYP19 gene expression. Prostaglandin E(2) (PGE(2)) stimulates the cyclic AMP (cAMP) → protein kinase A (PKA) → cAMP responsive element binding protein (CREB) pathway leading to increased CYP19 transcription. The… CONTINUE READING