The prostaglandin E2 and F2 alpha receptor genes are expressed in human myometrium and are down-regulated during pregnancy.

@article{Matsumoto1997ThePE,
  title={The prostaglandin E2 and F2 alpha receptor genes are expressed in human myometrium and are down-regulated during pregnancy.},
  author={Tadashi Matsumoto and Norimasa Sagawa and Munehito Yoshida and Takahide Mori and Isao Tanaka and Masashi Mukoyama and Motoko Kotani and Kazuwa Nakao},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={238 3},
  pages={838-41}
}
Prostaglandin (PG) E2 and PGF2 alpha are believed to play important roles in the myometrial contraction and the initiation of labor. Myometrial contraction by these prostanoids is mediated mainly through EP3 and FP, which are specific receptors to PGE2 and PGF2 alpha, respectively. During normal pregnancy, uterine myometrium are relaxed until term. To explore the involvement of EP3 and FP in the myometrial relaxation during pregnancy, we examined the EP3 and FP gene expressions in nonpregnant… CONTINUE READING

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