The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.

@article{Hayes1999ThePR,
  title={The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.},
  author={Justin S. Hayes and Orlaith A. Lawler and Mary T. Walsh and B. Therese Kinsella},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 34},
  pages={23707-18}
}
The prostacyclin receptor (IP), a G protein-coupled receptor, mediates the actions of the prostanoid prostacyclin and its mimetics. IPs from a number of species each contain identically conserved putative isoprenylation CAAX motifs, each with the sequence CSLC. Metabolic labeling of human embryonic kidney (HEK) 293 cells stably overexpressing the hemagluttinin epitope-tagged IP in the presence of [(3)H]mevalonolactone established that the mouse IP is isoprenylated. Studies involving in vitro… CONTINUE READING

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