The proprotein convertases furin and PACE4 play a significant role in tumor progression.

@article{Bassi2000ThePC,
  title={The proprotein convertases furin and PACE4 play a significant role in tumor progression.},
  author={Daniel E. Bassi and Haleh Mahloogi and Andr{\'e}s J. P. Klein-Szanto},
  journal={Molecular carcinogenesis},
  year={2000},
  volume={28 2},
  pages={63-9}
}
Processing of latent precursor proteins by proprotein convertases (PCs) into their biologically active products is a common mechanism required for many important biologic functions. This process is tightly regulated, leading to the generation of active peptides and proteins including neuropeptides and polypeptide hormones, protein tyrosine phosphatases, growth factors and their receptors, and enzymes including matrix metalloproteases (MMPs). These processing reactions occurs at pairs of basic… CONTINUE READING

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