The proprotein convertases and their implication in sterol and/or lipid metabolism

  title={The proprotein convertases and their implication in sterol and/or lipid metabolism},
  author={N. Seidah and A. Khatib and A. Prat},
  booktitle={Biological chemistry},
Abstract The proprotein convertases represent a family of nine proteinases, comprising seven basic amino acid-specific subtilisin-like serine proteinases related to yeast kexin, known as PC1/3, PC2, furin, PC4, PC5/6, PACE4 and PC7, and two other subtilases that cleave at non-basic residues, called SKI-1/S1P and NARC-1/PCSK9. The present review concentrates on the regulatory role played by some of these convertases in cholesterol and lipid metabolism. Thus, PC5/6, PACE4 and Furin upregulate… Expand
96 Citations
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