The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

@inproceedings{Iordanov2016ThePC,
  title={The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity},
  author={Iordan Iordanov and Csaba Mih{\'a}lyi and Bal{\'a}zs T{\'o}th and L{\'a}szl{\'o} Csan{\'a}dy},
  booktitle={eLife},
  year={2016}
}
Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death. TRPM2 is activated by ADP ribose (ADPR) binding to its C-terminal cytosolic NUDT9-homology (NUDT9H) domain, homologous to the soluble mitochondrial ADPR pyrophosphatase (ADPRase) NUDT9. Reported ADPR hydrolysis classified TRPM2 as a channel-enzyme, but insolubility of isolated NUDT9H hampered further investigations. Here we… CONTINUE READING
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