The prophylaxis and treatment of heterotopic ossification following lower limb arthroplasty.

@article{Board2007ThePA,
  title={The prophylaxis and treatment of heterotopic ossification following lower limb arthroplasty.},
  author={Tim N. Board and A R Karva and R E Board and Anil K. Gambhir and Martyn L Porter},
  journal={The Journal of bone and joint surgery. British volume},
  year={2007},
  volume={89 4},
  pages={434-40}
}
Heterotopic ossification following joint replacement in the lower limb occurs in 3% to 90% of cases. Higher grades of heterotopic ossification can result in significant limitation of function and can negate the benefits of joint replacement. The understanding of the pathophysiology of this condition has improved in recent years. It would appear to be related to a combination of systemic and local factors, including over-expression of bone morphogenetic protein-4. There is currently little… CONTINUE READING

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