The prophylactic use of tranexamic acid and aprotinin in orthotopic liver transplantation: a comparative study.

@article{Dalmau2004ThePU,
  title={The prophylactic use of tranexamic acid and aprotinin in orthotopic liver transplantation: a comparative study.},
  author={Ant{\`o}nia Dalmau and A. Fernandez Sabate and Maylin Koo and Carlos Bartolom{\'e} and Antoni G Rafecas and Joan Figueras and Eduard Jaurrieta},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  year={2004},
  volume={10 2},
  pages={
          279-84
        }
}
The efficacy of tranexamic acid (TA) and aprotinin (AP) in reducing blood product requirements in orthotopic liver transplantation (OLT) was compared in a prospective, randomized and double-blind study. One hundred and twenty seven consecutive patients undergoing OLT were enrolled; TA was administered to 64 OLT patients at a dose of 10mg /kg/h and aprotinin was administered to 63 OLT patients at a loading dose of 2 x 10(6) KIU followed by an infusion of 500,000 KIU/h. The portocaval shunt could… CONTINUE READING
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