The prophenoloxidase‐activating system in invertebrates

@article{Cerenius2004ThePS,
  title={The prophenoloxidase‐activating system in invertebrates},
  author={Lage Cerenius and Kenneth Söderhäll},
  journal={Immunological Reviews},
  year={2004},
  volume={198}
}
Summary:  A major innate defense system in invertebrates is the melanization of pathogens and damaged tissues. This important process is controlled by the enzyme phenoloxidase (PO) that in turn is regulated in a highly elaborate manner for avoiding unnecessary production of highly toxic and reactive compounds. Recent progress, especially in arthropods, in the elucidation of mechanisms controlling the activation of zymogenic proPO into active PO by a cascade of serine proteinases and other… Expand
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TLDR
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TLDR
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TLDR
This review highlights the recent discoveries of the critical roles of the proPO system in the shrimp immune responses against major pathogens, and emphasizes the functional characterizations of four major groups of genes and proteins in the pro PO cascade in penaeid shrimp, that is the PRPs, serine proteinases, proPO and inhibitors. Expand
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TLDR
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TLDR
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TLDR
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TLDR
The results suggest that lysozymes may inhibit the proPO activation system by preventing conversion of proPO to PO via direct protein interaction with proPO. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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