The properties of ryanodine-sensitive Ca(2+) release in mouse gastric smooth muscle cells.

@article{Tokutomi2001ThePO,
  title={The properties of ryanodine-sensitive Ca(2+) release in mouse gastric smooth muscle cells.},
  author={Yoshiko Tokutomi and Naofumi Tokutomi and Katsuhide Nishi},
  journal={British journal of pharmacology},
  year={2001},
  volume={133 1},
  pages={125-37}
}
1. Under voltage-clamped conditions, gastric smooth muscle cells of BALB/c mice developed spontaneous (STOCs) and caffeine- (I(CAF)) and carbachol-induced (I(CCh)) transient outward currents. 2. In fura-2 microscopic measurements of intracellular Ca(2+) concentration ([Ca(2+)](i)), caffeine and carbachol (CCh) provoked similar transient [Ca(2+)](i) elevations. 3. Both I(CCh) and CCh-induced [Ca(2+)](i) elevation of single smooth muscle cells occurred in an 'all-or-nothing' fashion in contrast… CONTINUE READING