The properties of human C5a anaphylatoxin. The significance of C5a formation during hemodialysis.

@article{Chenoweth1987ThePO,
  title={The properties of human C5a anaphylatoxin. The significance of C5a formation during hemodialysis.},
  author={D E Chenoweth},
  journal={Contributions to nephrology},
  year={1987},
  volume={59},
  pages={51-71}
}
Human C5a anaphylatoxin is a potent bioactive molecule that possesses both spasmogenic and leukocyte-related properties. As such, it normally serves as a local mediator of the acute inflammatory response. Additionally, C5a, through its actions of mononuclear phagocytes, may act to bridge the gap in the acute-chronic inflammatory continuum. While these properties are critical to normal host defense mechanisms, it is now apparent that this anaphylatoxin and/or its des-Arg74 derivative, may exert… CONTINUE READING

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