The propagation of binding interactions to remote sites in proteins: analysis of the binding of the monoclonal antibody D1.3 to lysozyme.

@article{Freire1999ThePO,
  title={The propagation of binding interactions to remote sites in proteins: analysis of the binding of the monoclonal antibody D1.3 to lysozyme.},
  author={Ernesto Freire},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 18},
  pages={10118-22}
}
  • Ernesto Freire
  • Published 1999 in
    Proceedings of the National Academy of Sciences…
The interaction of a ligand with a protein occurs at a local site (the binding site) and involves only a few residues; however, the effects of that interaction are often propagated to remote locations. The chain of events initiated by binding provides the basis for fundamental biological phenomena such as allosterism, signal transduction, and structural-stability modification. In this paper, a structure-based statistical thermodynamic approach is presented and used to predict the propagation of… CONTINUE READING

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