The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion

  title={The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion},
  author={B. Westerman and A. Poutsma and K. Maruyama and Henry F.J Schrijnemakers and I. V. Wijk and C. B. Oudejans},
  journal={Mechanisms of Development},
  • B. Westerman, A. Poutsma, +3 authors C. B. Oudejans
  • Published 2002
  • Biology, Medicine
  • Mechanisms of Development
  • During early human pregnancy, extravillous trophoblast cells invade the maternal tissue of the uterus in a way similar to invasion by cancer cells. However, the process of trophoblast invasion is regulated in a time and place restricted way, in contrast to cancer invasion. We screened first trimester placental tissue enriched by extravillous invasive trophoblasts for the expression of proneural basic helix-loop-helix (bHLH) transcription factors, which are important controllers of cell fate… CONTINUE READING
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