The promoter of the Immunoglobulin J Chain gene receives its authentic enhancer activity through the abutting MEF2 and PU.1 sites in a DNA-looping interaction.

@article{Lim2009ThePO,
  title={The promoter of the Immunoglobulin J Chain gene receives its authentic enhancer activity through the abutting MEF2 and PU.1 sites in a DNA-looping interaction.},
  author={Jung-Hyun Lim and Hong-Gi Kim and Sung-Kyun Park and C. Kang},
  journal={Journal of molecular biology},
  year={2009},
  volume={390 3},
  pages={
          339-52
        }
}
Immunoglobulin J chain (IgJ) promoter had previously been dissected in the context of a heterologous enhancer and/or promoter because its strength was weak and its authentic enhancer was not available at that time. Thus, it has been questioned whether the previous dissection of the IgJ promoter might also be relevant in the context of its authentic enhancer. Now that the authentic IgJ enhancer has been identified, redelineation of the IgJ promoter could be performed in the context of this… Expand
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TLDR
Interleukin-2 (IL-2)-induced transcription of the J chain gene was used as a model for analyzing cytokine regulation during B cell development and it was shown that the enhancer is activated at this stage by an IL-2 signal that functions by opening the enhancing chromatin and stimulating STAT5 to bind to a STAT5 element critical for the enhancers induction. Expand
Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element.
TLDR
An important role is established for PU.1 in the regulation of immunoglobulin J-chain gene expression and new insights are provided into the function(s) of the Ets transcription factors in lymphoid cells. Expand
B Cell-specific Activator Protein Prevents Two Activator Factors from Binding to the Immunoglobulin J Chain Promoter until the Antigen-driven Stages of B Cell Development*
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It is not until the levels of BSAP decrease during the antigen-driven stages of B cell development that both USF and B-MEF2 are able to bind to their respective promoter elements and activate J chaintranscription. Expand
A promoter element that exerts positive and negative control of the interleukin 2-responsive J-chain gene.
TLDR
In a primary immune response a signal from interleukin 2 (IL-2) induces B lymphocytes to express the gene for the IgM joining component, the J chain, and analysis of the J-chain gene 5' flanking region identified a major control region that encodes two adjacent elements: a T-rich sequence (JA) containing a single positive regulatory motif and an A+G-rich sequences (JB) containing overlapping positive and negative regulatory motifs. Expand
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