The promoter elements of the mouse myelin basic protein gene function efficiently in NG108-15 neuronal/glial cells.

@article{Miura1989ThePE,
  title={The promoter elements of the mouse myelin basic protein gene function efficiently in NG108-15 neuronal/glial cells.},
  author={Masami Miura and Tomonari Tamura and A Aoyama and Katuhiko Mikoshiba},
  journal={Gene},
  year={1989},
  volume={75 1},
  pages={31-8}
}
We measured transiently-expressed beta-galactosidase activity by introducing the mouse myelin basic protein (MBP)-lacZ chimeric gene (MBP-lacZ) into the NG108-15 neuronal/glial hybrid cell line. Deletion studies of the promoter region of the MBP gene showed that the promoter region between -1318 bp and -254 bp might contain sequences that repress MBP promoter activity. Fine deletion analysis using BAL 31 exonuclease revealed sequences between bp -208 and -140, -139 and -118, and -89 and -75… CONTINUE READING

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