The promises and pitfalls of RNA-interference-based therapeutics

  title={The promises and pitfalls of RNA-interference-based therapeutics},
  author={Daniela Castanotto and John J. Rossi},
The discovery that gene expression can be controlled by the Watson–Crick base-pairing of small RNAs with messenger RNAs containing complementary sequence — a process known as RNA interference — has markedly advanced our understanding of eukaryotic gene regulation and function. The ability of short RNA sequences to modulate gene expression has provided a powerful tool with which to study gene function and is set to revolutionize the treatment of disease. Remarkably, despite being just one decade… CONTINUE READING