The promise of single-cell sequencing

  title={The promise of single-cell sequencing},
  author={J. Eberwine and J. Sul and T. Bartfai and J. Kim},
  journal={Nature Methods},
  • J. Eberwine, J. Sul, +1 author J. Kim
  • Published 2013
  • Medicine, Biology
  • Nature Methods
  • Individual cells of the same phenotype are commonly viewed as identical functional units of a tissue or organ. However, the deep sequencing of DNA and RNA from single cells suggests a more complex ecology of heterogeneous cell states that together produce emergent system-level function. Continuing development of high-content, real-time, multimodal single-cell measurement technologies will lead to the ultimate goal of understanding the function of an individual cell in the context of its… CONTINUE READING

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    • 1,888
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