The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

@article{Zacchi2002ThePI,
  title={The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults},
  author={P. Zacchi and M. Gostissa and T. Uchida and Clio Salvagno and F. Avolio and S. Volinia and Z. Ronai and G. Blandino and C. Schneider and G. Sal},
  journal={Nature},
  year={2002},
  volume={419},
  pages={853-857}
}
  • P. Zacchi, M. Gostissa, +7 authors G. Sal
  • Published 2002
  • Medicine, Biology
  • Nature
  • The tumour suppressor p53 is important in the cell decision to either arrest cell cycle progression or induce apoptosis in response to a variety of stimuli. p53 post-translational modifications and association with other proteins have been implicated in the regulation of its stability and transcriptional activities. Here we report that, on DNA damage, p53 interacts with Pin1, a peptidyl-prolyl isomerase, which regulates the function of many proteins involved in cell cycle control and apoptosis… CONTINUE READING
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    References

    SHOWING 1-10 OF 30 REFERENCES
    Excess β‐catenin promotes accumulation of transcriptionally active p53
    • 118
    • PDF
    Mechanisms of p53-mediated apoptosis
    • 326
    p53 Death Star
    • 756
    Pin1 acts catalytically to promote a conformational change in Cdc25.
    • 170