The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

@article{Zacchi2002ThePI,
  title={The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults},
  author={Paola Zacchi and Monica Gostissa and Takafumi Uchida and Clio Salvagno and Fabio Avolio and Stefano Volinia and Ze’ev A. Ronai and Giovanni Blandino and Claudio Schneider and Giannino Del Sal},
  journal={Nature},
  year={2002},
  volume={419},
  pages={853-857}
}
The tumour suppressor p53 is important in the cell decision to either arrest cell cycle progression or induce apoptosis in response to a variety of stimuli. p53 post-translational modifications and association with other proteins have been implicated in the regulation of its stability and transcriptional activities. Here we report that, on DNA damage, p53 interacts with Pin1, a peptidyl-prolyl isomerase, which regulates the function of many proteins involved in cell cycle control and apoptosis… 
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TLDR
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TLDR
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TLDR
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Regulation of the p73 protein stability and degradation.
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TLDR
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