The prolyl isomerase Pin1 in breast development and cancer

  title={The prolyl isomerase Pin1 in breast development and cancer},
  author={Gerburg M Wulf and Akihide Ryo and Yih-Cherng Liou and Kun Lu},
  journal={Breast Cancer Research},
  pages={76 - 82}
The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer. Its overexpression can lead to upregulation of cyclin D1 and transformation of breast epithelial cells in collaboration with the oncogenic pathways. In contrast, inhibition of Pin1 can suppress the transformation of breast epithelial cells. In addition, Pin1… CONTINUE READING

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Pin1 is overexpressed in breast cancer and potentiates the transcriptional activity of phosphorylated c-Jun towards the cyclin D1 gene

  • GM Wulf, A Ryo, GG Wulf, SW Lee, T Niu, KP Lu
  • EMBO J
  • 2001
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