The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

@inproceedings{Sorrentino2013ThePP,
  title={The prolyl-isomerase Pin1 activates the mitochondrial death program of p53},
  author={Giovanni Sorrentino and M Mioni and Carlotta Giorgi and Naomi Ruggeri and Paolo Pinton and Ute M. Moll and Fiamma Mantovani and Giannino Del Sal},
  booktitle={Cell Death and Differentiation},
  year={2013}
}
In response to intense stress, the tumor protein p53 (p53) tumor suppressor rapidly mounts a direct mitochondrial death program that precedes transcription-mediated apoptosis. By eliminating severely damaged cells, this pathway contributes to tumor suppression as well as to cancer cell killing induced by both genotoxic drugs and non-genotoxic p53-reactivating molecules. Here we have explored the role had in this pathway by the prolyl-isomerase Pin1 (peptidylprolyl cis/trans isomerase, NIMA… CONTINUE READING
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