The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain.

@article{Sato2008ThePA,
  title={The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain.},
  author={Chiyo Sato and Atsushi Sakai and Yumiko Ikeda and Hidenori Suzuki and Atsuhiro Sakamoto},
  journal={Anesthesia and analgesia},
  year={2008},
  volume={106 1},
  pages={313-20, table of contents}
}
BACKGROUND In clinical practice, the analgesic effects of epidurally administered local anesthetics on chronic pain sometimes outlast the duration of drug action expected from their pharmacokinetics. To investigate the underlying mechanisms of this prolonged effect, we examined the effects of ropivacaine, a local anesthetic, on pain-related behavior in a rat model of neuropathic pain. We also analyzed changes in the expression of nerve growth factor (NGF), which is involved in plasticity of the… CONTINUE READING

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