The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene.

@article{Baati2012ThePO,
  title={The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene.},
  author={Tarek Baati and Fanchon Bourasset and N. Gharbi and Leila Njim and Manef Abderrabba and Abdelhamid Kerkeni and Henri Szwarc and Fathi Moussa},
  journal={Biomaterials},
  year={2012},
  volume={33 19},
  pages={
          4936-46
        }
}
Countless studies showed that [60]fullerene (C(60)) and derivatives could have many potential biomedical applications. However, while several independent research groups showed that C(60) has no acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and the chronic effects of this fullerene remain unknown. If the potential of C(60) and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we… Expand
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References

SHOWING 1-10 OF 68 REFERENCES
[60]fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity.
TLDR
Results show that aqueous C(60) suspensions prepared without using any polar organic solvent not only have no acute or subacute toxicity in rodents but they also protect their livers in a dose-dependent manner against free-radical damage. Expand
Toxicity studies of fullerenes and derivatives.
TLDR
If pristine C60 is absolutely nontoxic under dark conditions, this is not the case under UV-Visible irradiation and in the presence of O2 where ffullerene solutions can be highly toxic through 1O2 formation. Expand
Fullerenolates: metallated polyhydroxylated fullerenes with potent anti-amyloid activity.
TLDR
The observed pronounced anti-amyloid activity and low toxicity of NaFL make it a very promising lead drug for the development of potent fullerene-based therapeutic approaches for the treatment of amyloidoses, such as Alzheimer's disease and others. Expand
Clearance kinetics of fullerene C₆₀ nanoparticles from rat lungs after intratracheal C₆₀ instillation and inhalation C₆₀ exposure.
TLDR
The C( 60) burden in the lungs, liver, and brain of rats was determined by a newly developed sensitive high-performance liquid chromatography-ultraviolet absorptiometry combined with extraction and concentration of C(60) from the organs. Expand
Nanostructures of hydrated C60 fullerene (C60HyFn) protect rat brain against alcohol impact and attenuate behavioral impairments of alcoholized animals.
TLDR
Administration of aqueous solutions of hydrated C60 fullerenes with C60 concentration of 30nM as a drinking water during chronic alcoholization of rats protects the tissues of central nervous system from damage caused by oxidative stress with high efficacy and significantly improves behavioral response and eliminates emotional deficits induced by chronic alcohol uptake. Expand
Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostuctures in vitro and in vivo.
TLDR
Results of the study obviate that the apparent protective action of C(60)HyFn in vivo is determined by its considerable ability to decrease X-ray-generated reactive oxygen species, which substantially diminishes the harmful effects of ionizing radiation. Expand
Tumor-inhibitory effect and immunomodulatory activity of fullerol C60(OH)x.
TLDR
The results suggest that C60(OH)x can enhance the innate immunity of tumor-bearing mice, and therefore inhibits growth of the tumor. Expand
In vivo reaction between [60] fullerene and vitamin A in mouse liver
An invivo biotransformation of [60] fullerene is observed that does not follow a usual redox metabolic pathway. Following the administration of a single dose of micronized C60 to Swiss mice,Expand
Intrinsic biological property of colloidal fullerene nanoparticles (nC60): lack of lethality after high dose exposure to human epidermal and bacterial cells.
TLDR
A novel method for preparing nC60 nanoparticles that does not use THF solvent, but provides nC 60 with an average particle size of 43.8 nm and a yield approximately 100 times higher than the THF method is reported, confirming the prior non-toxic reports when using nC50 prepared with non-THF methods. Expand
Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells.
TLDR
Water-soluble C(60)fullerene derivatives synthesized to examine their bioactivities were sufficiently soluble in water and showed an enhancing effect on the neurite outgrowth of NGF-treated PC12 cells. Expand
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