The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain

@article{Mermod1989ThePT,
  title={The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain},
  author={Nicolas Mermod and E A O'neill and Thomas J. Kelly and Robert Tjian},
  journal={Cell},
  year={1989},
  volume={58},
  pages={741-753}
}
Human CTF/NF-I consists of a family of CCAAT box binding proteins that activate both transcription and DNA replication. Analysis of cDNA mutants expressed in E. coli and Drosophila cells reveals that the N-terminal portion of CTF-1 is sufficient for site-specific DNA recognition, protein dimerization, and adenovirus replication. In contrast, transcriptional activation requires an additional C-terminal domain. Furthermore, this transcription domain efficiently activates a heterologous promoter… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 146 extracted citations

24 Adenovirus DNA Replication

View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…