The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus.

@article{Djavani2005ThePH,
  title={The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus.},
  author={Mahmoud M Djavani and Ivan Topisirovic and Juan Carlos Zapata and Mariola Sadowska and Yida Yang and Juan David Rodas and Igor S. Lukashevich and Clifford W Bogue and C David Pauza and Katherine Lb Borden and Maria S. Salvato},
  journal={Journal of virology},
  year={2005},
  volume={79 4},
  pages={2461-73}
}
The proline-rich homeodomain protein, PRH/HEX, participates in the early development of the brain, thyroid, and liver and in the later regenerative processes of damaged liver, vascular endothelial, and hematopoietic cells. A virulent strain of lymphocytic choriomeningitis virus (LCMV-WE) that destroys hematopoietic, vascular, and liver functions also alters the transcription and subcellular localization of PRH. A related virus (LCMV-ARM) that does not cause disease in primates can infect cells… CONTINUE READING

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