The prolactin gene is expressed in the hypothalamic-neurohypophyseal system and the protein is processed into a 14-kDa fragment with activity like 16-kDa prolactin.

@article{Clapp1994ThePG,
  title={The prolactin gene is expressed in the hypothalamic-neurohypophyseal system and the protein is processed into a 14-kDa fragment with activity like 16-kDa prolactin.},
  author={Carmen Clapp and Luz M. Torner and Gabriel Guti{\'e}rrez-Ospina and Esteban Alc{\'a}ntara and F. J. L{\'o}pez-G{\'o}mez and Mamoru Nagano and Paul A. T. Kelly and Salvador Mej{\'i}a and Miguel Angel Morales and Gonzalo Mart{\'i}nez de la Escalera},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 22},
  pages={10384-8}
}
The 23-kDa form of prolactin (PRL) has been proposed to function as both a mature hormone and a prohormone precursor for different uniquely bioactive forms of the molecule. We have shown that the 16-kDa N-terminal fragment of PRL (16K PRL) inhibits angiogenesis via a specific receptor. In addition, 16K PRL stimulates natriuresis and diuresis in the rat, and kidney membranes contain high-affinity specific binding sites for this PRL fragment. 16K PRL can be derived from an enzymatically cleaved… CONTINUE READING
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