The prokaryotic V4R domain is the likely ancestor of a key component of the eukaryotic vesicle transport system

@article{Podar2008ThePV,
  title={The prokaryotic V4R domain is the likely ancestor of a key component of the eukaryotic vesicle transport system},
  author={Mircea Podar and Mark A Wall and Kira S. Makarova and Eugene V. Koonin},
  journal={Biology Direct},
  year={2008},
  volume={3},
  pages={2 - 2}
}
Intracellular vesicle traffic that enables delivery of proteins between the endoplasmic reticulum, Golgi and various endosomal subcompartments is one of the hallmarks of the eukaryotic cell. Its evolutionary history is not well understood but the process itself and the core vesicle traffic machinery are believed to be ancient. We show here that the 4-vinyl reductase (V4R) protein domain present in bacteria and archaea is homologous to the Bet3 subunit of the TRAPP1 vesicle-tethering complex… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 18 references

Similar Papers

Loading similar papers…