The proinflammatory cytokine tumor necrosis factor-α excites subfornical organ neurons.

@article{Simpson2017ThePC,
  title={The proinflammatory cytokine tumor necrosis factor-α excites subfornical organ neurons.},
  author={Nick J Simpson and Alastair V Ferguson},
  journal={Journal of neurophysiology},
  year={2017},
  volume={118 3},
  pages={
          1532-1541
        }
}
Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine implicated in cardiovascular and autonomic regulation via actions in the central nervous system. TNF-α-/- mice do not develop angiotensin II (ANG II)-induced hypertension, and administration of TNF-α into the bloodstream of rats increases blood pressure and sympathetic tone. Recent studies have shown that lesion of the subfornical organ (SFO) attenuates the hypertensive and autonomic effects of TNF-α, while direct administration of… CONTINUE READING
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