The proinflammatory CXC-chemokines GRO-α/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids

@article{Egesten2007ThePC,
  title={The proinflammatory CXC-chemokines GRO-α/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids},
  author={Arne Egesten and Mette Eliasson and Anders I. Olin and Jonas S Erjef{\"a}lt and Anders Bjartell and Per Sangfelt and Marie Carlson},
  journal={International Journal of Colorectal Disease},
  year={2007},
  volume={22},
  pages={1421-1427}
}
Ulcerative colitis is characterized by relapsing mucosal inflammation where the lesions include tissue-damaging granulocytes. In addition, T cells and natural killer (NK) cells play important pathophysiologic roles. Chemokines are a large family of peptides that play key roles in the regulation of inflammation. The CXC-chemokines, growth-related oncogene (GRO)-α/CXCL1 and interleukin (IL)-8/CXCL8, both recruit neutrophils and possess mitogenic properties, whereas the interferon-dependent CXC… CONTINUE READING

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