The progression of adriamycin-induced nephrotic syndrome in rats and the effect of captopril.

@article{Hall1986ThePO,
  title={The progression of adriamycin-induced nephrotic syndrome in rats and the effect of captopril.},
  author={Robert L. Hall and W L Wilke and Martin J. Fettman},
  journal={Toxicology and applied pharmacology},
  year={1986},
  volume={82 1},
  pages={164-74}
}
The progression of adriamycin-induced nephrotic syndrome in rats was studied over a 3-month period. The effect of an angiotensin-converting enzyme inhibitor, captopril, on this model of renal disease, was also studied. Two weeks following a single iv injection of adriamycin, rats were divided into two treatment groups: one received a daily po dose of captopril and the other received a placebo. Measurements of renal function were performed at 4, 8, and 11 weeks following the initiation of… CONTINUE READING

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