The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis.

@article{Raptopoulou2010ThePD,
  title={The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis.},
  author={Amalia P Raptopoulou and George Bertsias and Dimitrios Makrygiannakis and Panagiotis Verginis and Iraklis Kritikos and Maria Tzardi and Lars Klareskog and Anca Irinel Catrina and Prodromos I Sidiropoulos and Dimitrios T. Boumpas},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 7},
  pages={1870-80}
}
OBJECTIVE T cells play a major role in the pathogenesis of rheumatoid arthritis (RA). The programmed death 1 (PD-1)/programmed death ligand 1 (PDL-1) pathway is involved in peripheral tolerance through inhibition of T cells at the level of synovial tissue. The aim of this study was to examine the role of PD-1/PDL-1 in the regulation of human and murine RA. METHODS In synovial tissue and synovial fluid (SF) mononuclear cells from patients with RA, expression of PD-1/PDL-1 was examined by… CONTINUE READING

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